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March 3, 2026
Tumor cell derived CCL20 exacerbates the immunosuppressive microenvironment by recruiting CCR6+ Tregs in pancreatic cancer
LM
Ling-Dong Meng
LJ
Luyang Jiang
Shaoxing University
YL
Yang-Yang Liang
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Key Points
Tregs, or regulatory T cells, increase due to CCL20, creating an immunosuppressive environment.
The study indicates that CCL20 may be pivotal in recruiting CCR6+ Tregs in pancreatic cancer.
Assessment identifies the role of tumor-derived CCL20 in modifying the tumor microenvironment.
Findings highlight the need for targeted therapies against CCL20 to improve pancreatic cancer outcomes.
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Tumor cell derived CCL20 exacerbates the immunosuppressive microenvironment by recruiting CCR6+ Tregs in pancreatic cancer | Synapse
Cite This Study
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Meng et al. (Tue,) studied this question.
synapsesocial.com/papers/69a7604cc6e9836116a2ce48
https://doi.org/https://doi.org/10.1016/j.canlet.2026.218290