Characterization of Breakthrough Invasive Fungal Infections in Allogeneic Hematopoietic Cell Transplant Recipients Receiving Antifungal Prophylaxis | Synapse
March 3, 2026
Characterization of Breakthrough Invasive Fungal Infections in Allogeneic Hematopoietic Cell Transplant Recipients Receiving Antifungal Prophylaxis
Key Points
Breakthrough invasive fungal infections were identified in patients receiving antifungal prophylaxis, indicating a potential treatment failure.
In the cohort analysis, 22% of patients developed infections despite undergoing prophylaxis, highlighting the challenges in management.
The observational analysis evaluated infection types and pathogens in allogeneic hematopoietic cell transplant recipients to understand this clinical issue.
Findings emphasize the need for improved antifungal strategies to prevent infections in vulnerable transplant populations.