The AMPK activator A769662 promotes ferroptosis and suppresses disulfidptosis by inhibiting SLC7A11

Key Points

• A769662 significantly promotes ferroptosis by inhibiting the SLC7A11 transporter, impacting cell death pathways.
• Inhibition of SLC7A11 was marked by a notable 30% increase in cell death from ferroptosis.
• Analysis of various cellular conditions demonstrated that A769662 also suppresses disulfidptosis effectively.
• This work highlights potential therapeutic targets in the regulation of oxidative stress-induced cell death.