Development of extrusion-based 3D-printed chitosan/magnesium-doped nanohydroxyapatite scaffolds functionalized with icariin, lithium chloride and naringin for enhanced bone regeneration in vitro and in vivo | Synapse
March 3, 2026
Development of extrusion-based 3D-printed chitosan/magnesium-doped nanohydroxyapatite scaffolds functionalized with icariin, lithium chloride and naringin for enhanced bone regeneration in vitro and in vivo
Key Points
Bone regeneration improved significantly with scaffolds functionalized with icariin and naringin, promoting tissue growth.
In vitro tests showed up to 50% increase in cell activity within 7 days in scaffolds containing 5% magnesium.
Analysis involved both in vitro cellular studies and in vivo animal models, evaluating scaffold performance in bone repair.
Supports using 3D-printing technology to create tailored scaffolds for bone tissue engineering, indicating a promising direction for future therapies.