P504. Pränatale Cholinergänzung rettet Lern- und Gedächtnisdefizite bei Mäusen, die während der neurodevelopmental Phasen erhöhtem Kynureninsäure ausgesetzt waren.

Key Points

• Learning and memory deficits improve significantly with prenatal choline supplementation.
• Mice exposed to elevated kynurenic acid during neurodevelopment show notable deficits, which supplementation helps reverse.
• Observational analysis examines the effects of prenatal choline supplementation on cognitive function in developmental settings.
• These findings suggest that choline may play a critical role in mitigating cognitive impairments due to neurodevelopmental disruptions.