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HSPA1A and DNAJB1 regulate NELF condensate dynamics to safeguard transcriptional recovery under heat stress | Synapse
March 3, 2026
HSPA1A and DNAJB1 regulate NELF condensate dynamics to safeguard transcriptional recovery under heat stress
SJ
Shuyao Jiang
ZJ
Zixuan Jia
WZ
Wenxuan Zhu
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Key Points
Transcriptional recovery is safeguarded by the regulation of condensate dynamics involving HSPA1A and DNAJB1.
The study highlights the roles of specific molecular pathways in maintaining cellular function under heat stress.
Analysis of condensate dynamics is conducted during exposure to varying levels of heat stress.
Findings may enhance understanding of cellular resilience mechanisms, particularly in stressful environments.
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Jiang et al. (Sun,) studied this question.
synapsesocial.com/papers/69a76880badf0bb9e87e4e37
https://doi.org/https://doi.org/10.1016/j.molcel.2026.01.015