Recombinant vs Standard Influenza Vaccine in Adults With Severe Obesity: A Randomized Clinical Trial

Key Points

• This research aims to compare the immune responses elicited by recombinant versus standard influenza vaccines in adults with severe obesity.
• Randomized clinical trial design
• Participants included adults with severe obesity
• Administered recombinant vaccine and standard egg-based vaccine
• Measured humoral immune responses post-vaccination
• Recombinant vaccine led to stronger short-term immune responses than the standard vaccine
• Indicates a potential additional benefit for influenza prevention in adults with severe obesity