What question did this study set out to answer?

To investigate how meibum lipid saturation is related to dry eye, age, and sex.

April 1, 2026Open Access

Meibum Lipid Saturation Related to Dry Eye, Age, and Sex Using Nuclear Magnetic Resonance Spectroscopy

Key Points

To investigate how meibum lipid saturation is related to dry eye, age, and sex.
Utilized nuclear magnetic resonance spectroscopy to analyze meibum lipids.
Compared lipids in cohorts with and without dry eye.
Evaluated the effect of age and sex on lipid saturation levels.
Observed decreased meibum HCunsat in dry eye and associated conditions.
Found that HCunsat levels decrease with age.
Identified lipid saturation as a contributing factor to meibomian gland dysfunction.

Abstract

Meibum HCunsat decreases with age and is lower with dry eye, Sjögren's syndrome, and Parkinson's disease cohorts compared with a cohort without dry eye. This decrease in HCunsat is expected to contribute to lipid aggregation, decreased lipid spreading, and meibomian gland outflow. ¹H-NMR was effective for quantifying major meibum lipids.

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Discussion

Authors

Djihane Machane

Muhammed Shah Shaji

Douglas Borchman

Journals

Investigative Ophthalmology & Visual Science

Actions

Institutions

University of Louisville

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Building similarity graph...

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Meibum Lipid Saturation Related to Dry Eye, Age, and Sex Using Nuclear Magnetic Resonance Spectroscopy

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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