Exosomes of Porphyromonas gingivalis ‐Infected Macrophages Impair the Endothelial Barrier and Angiogenesis In Vitro

Key Points

• The aim is to explore how exosomes from Porphyromonas gingivalis-infected macrophages affect endothelial cell function.
• Investigated the effects of exosomes on HUVECs (human umbilical vein endothelial cells)
• Analyzed signaling pathways involved, specifically the Akt/mTOR pathway
• Exosomes from infected macrophages led to dysfunction in HUVECs
• The observed dysfunction was mediated partially through the Akt/mTOR pathway