Metronidazole versus Vancomycin for a Moderate Clostridioides difficile Infection Defined by the Japanese Severity Score (MN Criteria): A Propensity Score-Matched Cohort Study

Key Points

• To assess the effectiveness of metronidazole compared to vancomycin for treating moderate Clostridioides difficile infections.
• Conducted a single-center retrospective cohort study from 2011 to 2025.
• Identified adult inpatients with moderate CDI receiving either oral metronidazole or vancomycin.
• Employed propensity score matching to balance participant characteristics.
• Comparative effectiveness of metronidazole and vancomycin was evaluated based on patient outcomes.
• No specific numerical results were provided, but trends in effectiveness between the two treatments were observed.