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There is a deep and useful connection between statistical mechanics (the behavior of systems with many degrees of freedom in thermal equilibrium at a finite temperature) and multivariate or combinatorial optimization (finding the minimum of a given function depending on many parameters). A detailed analogy with annealing in solids provides a framework for optimization of the properties of very large and complex systems. This connection to statistical mechanics exposes new information and provides an unfamiliar perspective on traditional optimization problems and methods.
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Kirkpatrick et al. (Fri,) studied this question.
www.synapsesocial.com/papers/69d6c31739aaaf0da5ab3565 — DOI: https://doi.org/10.1126/science.220.4598.671
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:
Scott Kirkpatrick
C. D. Gelatt
M.P. Vecchi
Science
IBM Research - Thomas J. Watson Research Center
Instituto Venezolano de Investigaciones Científicas
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