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Many routinely used summary methods provide widely ranging estimates when applied to sparse data with high imbalance between the size of the studies' arms. A sensitivity analysis using several methods and continuity correction factors is advocated for routine practice.
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Sweeting et al. (Tue,) studied this question.
www.synapsesocial.com/papers/69d740e4f07a12db70b8a839 — DOI: https://doi.org/10.1002/sim.1761
Michael Sweeting
Alex J. Sutton
Paul C. Lambert
Statistics in Medicine
MRC Biostatistics Unit
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