Plasma serine and glycine in relation to clinical outcomes following neoadjuvant radiotherapy for rectal cancer

Key Points

• To explore the relationship between the plasma serine/glycine ratio and clinical outcomes following neoadjuvant radiotherapy for rectal cancer.
• Measured plasma serine and glycine levels in rectal cancer patients
• Analyzed the serine/glycine ratio in relation to clinical outcomes
• Investigated the role of SHMT enzyme activity
• Found a potential association between serine/glycine ratio and rectal cancer recurrence
• Indicated a need for further studies to confirm these findings
• Suggested exploring strategies to target SHMT activity in cancer treatment

Abstract