Structure-oriented Screening of New Natural Products from Microorganisms

New natural products are the starting point for related research areas such as drug development, biosynthesis, mode of action, and organic synthesis. However, intensive screening activity over the past decades has led to frequent reisolation of known compounds. With the first priority to obtain new chemical structures, we have employed HPLC/UV-guided chemical screening instead of activity-guided screening. In this article, new compounds discovered in our laboratory are presented, focusing on structural features, structure determination, biosynthesis, and synthetic studies.