Regulatory Roles of Long Non-Coding RNAs in Methotrexate Pharmacology: Mechanistic and Translational Insights

Key Points

• The research aims to understand how long non-coding RNAs (lncRNAs) influence the pharmacokinetics and pharmacodynamics of methotrexate (MTX).
• Review current evidence on lncRNA functions in MTX pharmacology
• Discuss the integration of functional genomics with pharmacokinetic measurements
• Highlight the need for prospective clinical validation
• lncRNAs act as context-dependent modulators rather than direct drug targets
• Current evidence regarding lncRNAs in MTX regulation is inconsistent
• Future studies are necessary to explore lncRNAs as biomarkers or therapeutic targets

Abstract