Antiepileptic potential of Jatropha integerrima Jacq. extracts: an exploratory study integrating in vivo seizure models and computational analysis

Key Points

• The study aims to explore the antiepileptic properties of Jatropha integerrima using both animal models and computational methods.
• Extracted compounds from Jatropha integerrima using ethanol, then fractionated into petroleum ether and ethyl acetate.
• Conducted tests for anticonvulsant activity in Swiss albino mice using pentylenetetrazol and maximal electroshock seizure models.
• Performed molecular docking and MM/GBSA analyses to evaluate binding affinities of compounds with GABAA and Nav1.2 receptors.
• Conducted ADME and toxicity predictions and molecular dynamics simulations to assess pharmacokinetics.
• The petroleum ether fraction significantly reduced seizure frequency and duration compared to controls (<p< 0.05).
• The lead compound (-)-jatrointelignan A showed strong binding affinities for GABAA and Nav1.2 receptors.
• Pharmacokinetic predictions indicated favorable properties and low toxicity for the extracts.

Abstract