The Non-Coding Code: Silent Regulators of MEG3 and Let-7i-3p/5p in the Progression of Acute Lymphoblastic Leukemia

This study demonstrates that adult ALL patients exhibit hematological abnormalities including anemia, leukopenia, and thrombocytopenia. Molecular analysis revealed a significant downregulation of lncRNA MEG3, alongside upregulation of let-7i-3p/5p, suggesting their potential involvement in leukemogenesis. These findings highlight the diagnostic and possibly prognostic relevance of MEG3 and let-7i in adult ALL and provide a basis for further investigation into their mechanistic roles and therapeutic targeting.