Dementia Incidence in Individuals With Parkinson's Disease in the Framingham Heart Study

Limited information exists on incident dementia in individuals with Parkinson's disease (PD) in US community-based samples. We examined cognitive statuses and PD diagnoses of 183 individuals in the Framingham Heart Study (FHS) to establish incident dementia, mortality rates, associations with sex, age at PD onset, and education level. Annual incidence rates of dementia (5.0%, 95% CI 3.7%-6.4%) and mortality (10.5%, 95% CI 8.7%-12.3%), did not differ by sex or education level. Increased age at PD diagnosis was a significant risk factor for incident dementia and mortality. Sex may not be a significant risk factor for community-based PD dementia.