Design, synthesis, and characterization of guanidine derivative with broad-spectrum antimicrobial and antidiabetic inhibitory activities: a comprehensive spectroscopic and computational study

Key Points

• The study aims to design and characterize a guanidine derivative with antimicrobial and antidiabetic properties.
• Synthesis of a novel guanidine derivative
• Spectroscopic characterization to assess chemical properties
• Computational analysis to predict pharmacokinetics
• In vitro testing for antimicrobial activity and α-amylase inhibition
• The guanidine derivative exhibits broad-spectrum antimicrobial activity.
• Significant inhibition of α-amylase activity is observed.
• Optimization is recommended for improved efficacy and pharmacokinetics.

Abstract