What question did this study set out to answer?

To investigate the clinical implications of anti-RNPC3 autoantibodies in mixed connective tissue disease (MCTD).

April 10, 2026Open Access

Clinical Associations of Anti‐ RNPC3 Autoantibodies in Mixed Connective Tissue Disease

Key Points

To investigate the clinical implications of anti-RNPC3 autoantibodies in mixed connective tissue disease (MCTD).
Analyzed the frequency of skin involvement in patients with MCTD and its association with anti-RNPC3 autoantibodies.
Assessed the potential link between high titers of anti-RNPC3 autoantibodies and cancer risk in MCTD patients.
Patients with higher titers of anti-RNPC3 autoantibodies showed increased skin involvement related to scleroderma.
The presence of anti-RNPC3 autoantibodies may indicate an elevated risk of cancer in patients with MCTD.

Abstract

Anti-RNPC3 autoantibodies were associated with a higher frequency of SSc skin involvement in patients with MCTD. Anti-RNPC3 autoantibodies, especially in high titers, might be the markers for an increased risk of cancer in MCTD that needs to be confirmed in larger cohorts.

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Discussion

Authors

Darya S. Jalaledin

Hajar El Kamouni

Alexandra Albert

Journals

ACR Open Rheumatology

Actions

Institutions

University of Calgary

Centre Hospitalier de l’Université de Montréal

Hôpital du Sacré-Cœur de Montréal

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Clinical Associations of Anti‐ RNPC3 Autoantibodies in Mixed Connective Tissue Disease

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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