Genetic Polymorphisms in Genes Involved in Oxidative Stress and Their Association with Radiotherapy Toxicity among Head and Neck Cancer Patients

Key Points

• This research aims to explore the link between genetic polymorphisms in oxidative stress-related genes and radiotherapy toxicity in head and neck cancer patients.
• Analyzed genetic polymorphisms in extracellular superoxide dismutase (SOD3)
• Assessed radiation-induced skin toxicity
• Evaluated mucositis severity among head and neck cancer patients
• Identified significant association of SOD3 polymorphisms with radiation-induced skin toxicity
• Found correlation between SOD3 variants and mucositis severity among patients

Abstract