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IgLON5 Autoimmune Antibody Influence On Neurons- Code | Synapse

April 10, 2026Open Access

IgLON5 Autoimmune Antibody Influence On Neurons- Code

Key Points

This analysis aims to assess the influence of IgLON5 autoimmune antibodies on neuronal behavior in specific brain regions.
Code provided for analyzing neurons from the hippocampus and cortex
Experiments include stimulation with IgLON5, IgG, and PBS
Data is reproducible based on previous findings by Askin et al.
The analysis aims to reproduce results from a prior study
Effects of different stimulation conditions on neuronal activity were evaluated

Abstract

This repository contains the code written by Pia Grundschöttel to analyze neurons from the hippocampus and cortex stimulated with IgLON5, IgG and PBS to reproduce the results of the manuscript Askin et al., Science Advances, 2026.Additional information can be requested by the authors and data is available under the following GEO accession numbers: GSE298951.

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Authors

P

Pia Grundschöttel

T

Thomas Ulas

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Institutions

German Center for Neurodegenerative Diseases

References and Citations

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Cite this study

Grundschöttel et al. (Tue,) studied this question.

www.synapsesocial.com/papers/69d895046c1944d70ce05fff — DOI: https://doi.org/10.5281/zenodo.19454005