What question did this study set out to answer?

To evaluate how thinning of the inner retinal layer affects visual function in individuals with OPA1-related autosomal dominant optic atrophy (ADOA).

April 10, 2026Open Access

Impact of Inner Retinal Layer Thinning on Visual Function in OPA1 Autosomal Dominant Optic Atrophy and Associations With Age and Genetic Variant Class

Key Points

To evaluate how thinning of the inner retinal layer affects visual function in individuals with OPA1-related autosomal dominant optic atrophy (ADOA).
Analyzed the relationship between inner retinal layer thickness and visual acuity (VA) in ADOA patients.
Measured mGCL (macular ganglion cell layer) thickness in the PMB (parafoveal macular bag) subfield.
Considered patient age and genetic variant types as influencing factors.
Significant association found between inner retinal layer thickness and severity of visual acuity and central scotoma.
mGCL thickness was a key predictor of visual function changes.
Worse visual outcomes noted in heterozygous individuals with missense variants in OPA1.

Abstract

VA and central scotoma severity in OPA1-related ADOA are significantly associated with inner retinal layer thickness, which is impacted by patient age. The mGCL thickness and sensitivity in the PMB subfield were the most indicative clinical parameters for disease-related changes, with worse outcomes in heterozygotes with missense variants in OPA1.

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Discussion

Authors

Johannes Schrittwieser

Andreas Reitner

Karl Kircher

Journals

Investigative Ophthalmology & Visual Science

Actions

Institutions

Medical University of Vienna

References and Citations

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Impact of Inner Retinal Layer Thinning on Visual Function in OPA1 Autosomal Dominant Optic Atrophy and Associations With Age and Genetic Variant Class

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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