An Optimized Potent Barrier‐Restoring Cream for Skin Repair: A Multicenter, Randomized, Double‐Blind, Split‐Face Controlled Clinical Study

Background and Objectives Severe sensitive skin significantly impairs patients’ quality of life, and moisturizer application has become a clinical imperative in its management. This study was designed to assess the skin barrier repair efficacy of an optimized, potent cream comprising Portulaca oleracea extract, Prinsepia utilis oil, Citrus reticulata peel extract, and Polygonatum kingianum extract. Materials and Methods A total of 103 eligible participants with sensitive skin were randomly assigned to apply the test cream (Cream A) on one cheek (left or right) and the control cream (Cream B) on the contralateral cheek, twice daily. Transepidermal water loss (TEWL), stratum corneum hydration (SCH), and erythema index (EI) were measured on both cheeks at baseline, as well as at 7, 14, and 28 days after product application. Clinical evaluations by two dermatologists and self‐reports by participants were carried out at identical time points. Results Both clinical evaluations and participant self‐reports revealed that the application of either Cream A or Cream B significantly relieved discomfort symptoms, including erythema and burning sensations; Cream A demonstrated a faster alleviation of desquamation symptoms. Both creams significantly improved TEWL, SCH, and EI in participants with sensitive skin. Notably, compared to Cream B, Cream A achieved a significantly higher improvement rate in EI at Day 7 ( p < 0.05) and a greater improvement rate in TEWL at Day 28 ( p < 0.05). Conclusion Cream A exhibits a remarkable clinical value in rapidly alleviating erythema and desquamation, with notable advantages in restoring damaged skin barriers, serving as a novel long‐term management strategy for sensitive skin. Trial Registration: National Medical Research Registration and Filing Information System: MR‐33‐24‐019764