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Objective determination of PD-L1 protein levels in NSCLC reveals heterogeneity within tumors and prominent interassay variability or discordance. This could be due to different antibody affinities, limited specificity, or distinct target epitopes. Efforts to determine the clinical value of these observations are under way.
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Joseph McLaughlin
Gang Han
Kurt A. Schalper
JAMA Oncology
Yale University
Cleveland Clinic
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McLaughlin et al. (Thu,) studied this question.
www.synapsesocial.com/papers/69d96ebcda3af5b1d08368a8 — DOI: https://doi.org/10.1001/jamaoncol.2015.3638