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Olaparib has few of the adverse effects of conventional chemotherapy, inhibits PARP, and has antitumor activity in cancer associated with the BRCA1 or BRCA2 mutation. (ClinicalTrials.gov number, NCT00516373.)
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Peter C.C. Fong
David S. Boss
Timothy A. Yap
New England Journal of Medicine
King's College London
Utrecht University
The Netherlands Cancer Institute
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Fong et al. (Wed,) studied this question.
www.synapsesocial.com/papers/69daa60385037e71b2684675 — DOI: https://doi.org/10.1056/nejmoa0900212