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In melanoma cell lines, including BRAFi-resistant cells, PD-L1 expression is variably regulated by oncogenic signaling pathways. PD-L1-exposed lymphocytes decrease MAPK signaling, which is corrected by exposure to vemurafenib, providing potential benefits of combining this drug with immunotherapies.
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Mohammad Atefi
Earl Avramis
Amanda Lassen
Clinical Cancer Research
University of California, Los Angeles
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Atefi et al. (Fri,) studied this question.
www.synapsesocial.com/papers/69dd4c8a0644c7b49d40cc18 — DOI: https://doi.org/10.1158/1078-0432.ccr-13-2797