Methylation of Tenascin XB mediated by Methyltransferase-like 3 can effectively suppress neural injury and cellular apoptosis induced by ischemic stroke

Key Points

• The study aims to investigate how METTL3-mediated methylation of TNXB can prevent neural injury and cellular apoptosis following ischemic stroke.
• Examined the role of METTL3 in methylating TNXB
• Assessed the relationship between m6A methylation and cellular damage in neural cells exposed to ischemic conditions
• Analyzed the potential therapeutic effects of targeting the METTL3-TNXB axis
• METTL3 methylation stabilizes TNXB expression
• Targeting this pathway reduces cellular damage caused by ischemic stroke
• Lower levels of cellular apoptosis were observed when METTL3 is active

Abstract