SemaGBA : A System Dynamics Model of the Semaglutide‐Responsive Gut‐Brain Axis A Model of How the Brain and Semaglutide Regulate Appetite and Weight

Key Points

• The aim is to explore how semaglutide influences appetite and weight through metabolic and neural interactions.
• Developed a system dynamics model to simulate the gut-brain axis effects of semaglutide.
• Analyzed pathways involved in glucose regulation and appetite control.
• Conducted a validation to assess model effectiveness based on available data.
• Model illustrates how semaglutide affects appetite regulation and glucose metabolism.
• Findings suggest potential neural mechanisms that could be further investigated with more data.

Abstract