Panton-Valentine Leukocidin Producing Staphylococcus aureus Causing Acute Hematogenous Osteomyelitis in the Pediatric Population: Implications on Clinical Course and Outcome

Key Points

• To explore the impact of Panton-Valentine leukocidin (PVL) producing Staphylococcus aureus on the severity of acute hematogenous osteomyelitis in pediatric patients.
• Analyzed clinical courses of pediatric patients with PVL-positive S. aureus infections.
• Documented incidence of severe cases and associated complications like subperiosteal abscess.
• Observed treatment outcomes and necessity for surgical interventions.
• 97.3% of patients tested positive for PVL-producing S. aureus.
• A significant portion exhibited severe clinical courses requiring intervention.
• Subperiosteal abscesses were common, necessitating surgical drainage in many cases.

Abstract