Fluoxetine Alleviates Vascular Cognitive Impairment by Activating the Nrf2/ARE Pathway via Sp1-Mediated OTUD1 Transcription

Key Points

• The aim is to investigate fluoxetine's effect on cognitive impairment related to cerebrovascular disease (CSVD) through specific molecular pathways.
• Examined fluoxetine's influence on cognitive function related to CSVD
• Analyzed the role of Sp1 in regulating OTUD1 expression
• Investigated the activation of the Nrf2/ARE pathway
• Fluoxetine effectively improved cognitive function associated with CSVD
• Confirmed Sp1 upregulates OTUD1 expression
• OTUD1 activation led to the stimulation of the Nrf2/ARE pathway

Abstract