Preliminary study on targeted nanoparticles co-loaded with piperine and paclitaxel prodrug for ovarian cancer treatment

Key Points

• The research aims to enhance the efficacy of ovarian cancer treatment using co-loaded nanoparticles with piperine and paclitaxel prodrug.
• Developed targeted, stimuli-responsive nanoparticle system
• Combined piperine and paclitaxel prodrug for treatment
• Evaluated anticancer efficacy and systemic toxicity
• Demonstrated improved anticancer efficacy compared to single agents
• Reduced systemic toxicity observed in preclinical models
• Targeted delivery increased drug accumulation at tumor sites