What question did this study set out to answer?

This research aims to explore how transauricular vagus nerve stimulation affects visceral hypersensitivity through specific signaling pathways.

April 15, 2026Open Access

Frequency‐Dependent Effects of Transauricular Vagus Nerve Stimulation on Alleviating Visceral Hypersensitivity: Involvement of the Nesfatin‐1/ CRF / CRF1R Pathway

Key Points

This research aims to explore how transauricular vagus nerve stimulation affects visceral hypersensitivity through specific signaling pathways.
Utilized transauricular vagus nerve stimulation on rats
Assessed visceral pain through behavioral responses
Investigated the nesfatin-1/CRF/CRF1R signaling pathway's involvement
Compared effects of different stimulation frequencies
Transauricular vagus nerve stimulation significantly reduced visceral pain
2 Hz stimulation had a stronger analgesic effect than other frequencies
Nesfatin-1/CRF/CRF1R pathway was implicated in the pain relief mechanism

Abstract

This study demonstrated that taVNS alleviates VH, potentially via the nesfatin-1/CRF/CRF1R signaling pathway in the rat hypothalamus. Furthermore, the analgesic effect was frequency-dependent, with 2 Hz taVNS providing a more effective reduction in visceral pain.

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Discussion

Authors

Wei Xu

Ziqin Zhou

Shuai Zhou

Journals

Neurogastroenterology & Motility

Actions

Institutions

Nanjing Medical University

Jiangsu Vocational College of Medicine

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Frequency‐Dependent Effects of Transauricular Vagus Nerve Stimulation on Alleviating Visceral Hypersensitivity: Involvement of the Nesfatin‐1/ CRF / CRF1R Pathway

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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