Accelerated long-read variant calling with Clair3 for whole-genome sequencing

Key Points

• The central aim is to enhance the accuracy and speed of variant calling in whole-genome sequencing using Clair3.
• Utilized Clair3 for variant calling on long-read sequences from whole-genome samples.
• Compared variant calling performance with existing methods.
• Analyzed computational time and accuracy metrics.
• Clair3 significantly improved variant calling accuracy over traditional methods.
• Reduced computational time for processing whole-genome sequences.
• Achieved higher sensitivity and specificity in identifying variants.

Abstract