What question did this study set out to answer?

The study aims to evaluate how well plasma p-tau217 can predict beta-amyloid status in patients.

April 15, 2026Open Access

Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study

Key Points

The study aims to evaluate how well plasma p-tau217 can predict beta-amyloid status in patients.
Conducted in a multicenter memory-clinic cohort
Plasma p-tau217 levels measured on an automated platform
Assessment made to discriminate CSF Aβ status
Plasma p-tau217 accurately discriminated beta-amyloid status
Enabled reliable classification in over half of patients
Findings support broader clinical use as a diagnostic tool for Alzheimer's disease

Abstract

In a real-world multicenter memory-clinic cohort, plasma p-tau217 measured on a fully automated platform accurately discriminated CSF Aβ status and enabled reliable rule-in/rule-out classification in over half of patients. These findings support its broader clinical use as an initial diagnostic tool for AD.

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Authors

Miquel Massons

Núria Guillén

Jordi Sarto

Journals

Annals of Clinical and Translational Neurology

Actions

Institutions

Universitat de Barcelona

Hospital Clínic de Barcelona

Biomedical Research Networking Center on Neurodegenerative Diseases

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study

Key Points

Abstract

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Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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