Responsible cell type in murine PAF-induced systemic anaphylaxis

Key Points

• To identify the principal cell type that mediates mortality in systemic anaphylaxis induced by platelet-activating factor (PAF).
• Utilized murine models with endothelial cell-specific PAFR deficiencies
• Induced systemic anaphylaxis using platelet-activating factor
• Assessed mortality rates in different cell types
• Endothelial cell-specific PAFR-deficient mice showed protection from mortality during anaphylaxis
• Findings suggest endothelial cells as the main target for PAF in inducing severe anaphylactic responses