Donor selection for patients with HLA-homozygous haplotypes in allogeneic hematopoietic stem cell transplantation

Key Points

• To evaluate the impact of donor selection on overall survival in HLA-homozygous transplant recipients.
• Registry analysis of first allogeneic transplants
• Comparison of related vs. cord blood donor outcomes
• Focus on survival rates in different donor scenarios
• Overall survival rates did not significantly differ between related donor hetero-to-homo and cord blood hetero-to-homo transplantation.
• Cord blood homo-to-homo transplantation was linked to worse survival outcomes.