What question did this study set out to answer?

The study aims to compare nephrotoxicity effects of Lutetium-177 PSMA I&T radioligand therapy vs. docetaxel in mCRPC patients.

April 18, 2026Open Access

Assessment of nephrotoxicity following lutetium-177 PSMA I&T radioligand therapy: a comparative study with docetaxel chemotherapy

Key Points

The study aims to compare nephrotoxicity effects of Lutetium-177 PSMA I&T radioligand therapy vs. docetaxel in mCRPC patients.
Retrospective multicenter analysis of 184 patients treated with either 177Lu-PSMA I&T or docetaxel.
Patient inclusion required specific treatment cycles and at least 12 months of eGFR follow-up.
Linear mixed models were utilized to assess longitudinal eGFR changes while adjusting for renal risk factors.
Mean eGFR decline was observed in both treatment subgroups treated with 177Lu-PSMA I&T compared to docetaxel.
Severe eGFR decline (≥ 30%) occurred more frequently in 177Lu-PSMA I&T patients than in docetaxel patients (p < 0.001).
The study corroborated a significant time-dependent eGFR decline with 177Lu-PSMA I&T regardless of prior chemotherapy exposure.

Abstract

To compare changes in estimated glomerular filtration rate (eGFR) following Lutetium-177 prostate-specific membrane antigen I post-chemo: 31.0% vs. 2.6%, OR = 17.1; both p < 0.001). LMM confirmed a significant time-dependent eGFR decline with ¹⁷⁷Lu-PSMA I pre-chemo β=-1.41; both p < 0.001). 177Lu-PSMA I&T is associated with a gradual, time-dependent decline in renal function compared with docetaxel, independent of prior chemotherapy exposure and baseline renal risk factors. These findings highlight the importance of baseline renal assessment and longitudinal kidney function monitoring, particularly as 177Lu-PSMA RLT is increasingly considered earlier in the treatment course.

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Authors

Florian P Kirchhoff

Lisa Steinhelfer

Christian H. Pfob

Journals

European Journal of Nuclear Medicine and Molecular Imaging

Actions

Institutions

Technical University of Munich

Klinikum rechts der Isar

Universitätsklinikum Würzburg

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Assessment of nephrotoxicity following lutetium-177 PSMA I&T radioligand therapy: a comparative study with docetaxel chemotherapy

Key Points

Abstract

Citation Network

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Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

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Discussion

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