What question did this study set out to answer?

To explore the relationship between SOD2 genetic variants and hepatotoxicity in pediatric leukemia across different ethnic groups.

May 7, 2026Pediatric Blood & Cancer0 citationsOpen Access

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Ethnic Differences in the Association Between SOD2 rs4880 and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia: A Report From the REDIAL Consortium

EMEmily J. Mason JWJohn P. Woodhouse JYJoanna S. Yi

Key Points

To explore the relationship between SOD2 genetic variants and hepatotoxicity in pediatric leukemia across different ethnic groups.
Analyzed genetic data from children with Acute Lymphoblastic Leukemia
Compared hepatotoxicity rates between Hispanic and non-Hispanic children
Calculated adjusted odds ratios for hepatotoxicity linked to SOD2 rs4880 variant.
Hispanic children showed increased odds of hepatotoxicity (aOR = 1.81) associated with SOD2 rs4880 variant
Non-Hispanic children demonstrated decreased odds of hepatotoxicity (aOR = 0.55)
Evidence of genetic variations impacting hepatotoxic risk across ethnicities.

Abstract

), but decreased odds in non-Hispanic children (aOR = 0.55, 95% CI: 0.32-0.94, p = 0.03). These findings highlight potential ethnicity-specific differences in genetic contributors to TAH risk and highlight the need for mechanistic studies.

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Cite This Study

Mason et al. (Tue,) studied this question.

synapsesocial.com/papers/69fbe3aa164b5133a91a2ddd https://doi.org/https://doi.org/10.1002/1545-5017.70387

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