What question did this study set out to answer?

May 7, 2026Journal of Veterinary Pharmacology and Therapeutics0 citations

Pharmacokinetic Profiles of Enrofloxacin and Its Metabolite Ciprofloxacin Administered by Different Doses in Calves

KÜKamil Üney OÇOrhan Çorum MYMurat Yüksel

Key Points

This research aims to assess the pharmacokinetic profiles of enrofloxacin and its metabolite ciprofloxacin in calves under different dosing conditions.
Administered enrofloxacin and ciprofloxacin at varying doses to calves.
Monitored pharmacokinetic profiles for dose-dependent changes.
Evaluated the conversion ratio of enrofloxacin to ciprofloxacin.
Ciprofloxacin levels increased in a dose-dependent manner (p < 0.05).
No significant alteration in the conversion ratio of enrofloxacin to ciprofloxacin (26%-28%, p > 0.05).
Pharmacokinetics exhibited considerable variability based on dosage.

Abstract

of CIP increased in a dose-dependent manner (p 0.05). The results of the current investigation demonstrated that the pharmacokinetics of ENR and CIP in calves had considerable variability with dose. Assessing dose-dependent pharmacokinetic alterations in calves can aid in establishing the dosing regimen; however, additional research is required to confirm dose-dependent therapeutic efficacy and safety.

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Üney et al. (Mon,) studied this question.

synapsesocial.com/papers/69fbefc0164b5133a91a3bb6 https://doi.org/https://doi.org/10.1111/jvp.70081

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