Inhibitory effects of thiophene-2-thiazole hybrids against sensitive strains and resistant clinical isolates of Mycobacterium tuberculosis

Key Points

• The research aims to evaluate the bactericidal effects of thiophene-2-thiazole hybrids against various strains of Mycobacterium tuberculosis.
• Assessed bactericidal activity of compound 3c under nutrient-starvation conditions.
• Compared performance against isoniazid in a dormancy model.
• Conducted cytotoxicity assays in HepG2 and Vero E6 cells.
• Compound 3c showed significant bactericidal activity, outperforming isoniazid in dormancy conditions.
• Low cytotoxicity was observed with an IC₅₀ value greater than 100 μM.