Improved Tumor Penetration and Single-Cell Targeting of Antibody–Drug Conjugates Increases Anticancer Efficacy and Host Survival

Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. Multiscale Modeling of Antibody-Drug Conjugates: Connecting Tissue and Cellular Distribution to Whole Animal Pharmacokinetics and Potential Implications for Efficacy· 2016 · 112 citations
2. Combined blockade of HER2 and VEGF exerts greater growth inhibition of HER2-overexpressing gastric cancer xenografts than individual blockade· 2013 · 39 citations
3. A novel method to quantify IRDye800CW fluorescent antibody probes ex vivo in tissue distribution studies· 2012 · 58 citations
4. Rapid blood clearance of mouse IgG2a and human IgG1 in many nude and nu /+ mouse strains is due to low IgG2a serum concentrations· 1998 · 39 citations
5. Effects of Drug Loading on the Antitumor Activity of a Monoclonal Antibody Drug Conjugate· 2004 · 1,202 citations