Supplementary Figure 13 from SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

Key Points

• CD8 T-cell dysfunction drives immunotherapy resistance in clear-cell renal cell carcinoma.
• Identification of T cells was performed through CyTOF, highlighting significant cellular alterations.
• Analysis utilized CyTOF to assess the impact of tumor-associated macrophages on T-cell function.
• Findings suggest potential targets for enhancing immunotherapy efficacy in renal cell carcinoma.

Abstract