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This research aims to explore how Engrailed-1 can prevent scarring after glaucoma surgery and its underlying mechanisms.

February 8, 2026Open Access

The Molecular Mechanisms and Therapeutic Potentials of Engrailed-1 in Fibrotic Scar Formation Post Glaucoma Filtration Surgery

This research aims to explore how Engrailed-1 can prevent scarring after glaucoma surgery and its underlying mechanisms.
Investigated molecular mechanisms behind fibrotic scar formation
Developed and tested Gel-Exo-siEN1 as an intervention
Analyzed outcomes post glaucoma filtration surgery
Gel-Exo-siEN1 significantly reduced fibrotic scar formation
Improved surgical outcomes were observed in models tested
Demonstrated potential for enhancing recovery after glaucoma surgery

Gel-Exo-siEN1 is a promising strategy for preventing postsurgical scarring and improving the outcomes of glaucoma surgery.

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Yi Lin

Wangdu Luo

Xiaomin Zhu

Investigative Ophthalmology & Visual Science

Chongqing Medical University

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