Regulatory dynamics of IFI44L in systemic lupus erythematosus: the interplay of type I interferon and c-Jun

Key Points

• Enhanced expression of IFI44L indicates its critical role in systemic lupus erythematosus.
• Type I interferon was shown to increase IFI44L expression by engaging c-Jun, affecting disease dynamics.
• Assessment suggests modulation of IFI44L expression could be a target for therapeutic intervention in autoimmune conditions.
• The findings highlight the importance of regulatory mechanisms involving IFN-α and c-Jun in the pathogenesis of SLE.