March 3, 2026Clinical and Translational Gastroenterology0 citationsOpen Access

Urine Proteomics Identifies Biomarkers for Diagnosis and Fibrosis Severity in Pediatric Chronic Pancreatitis

MMMadalyn G. MooreThe Ohio State University VGVineet GarlapallyCincinnati Children's Hospital Medical Center KBKatelyn B. BrusachThe Ohio State University

Key Points

Diagnosis of chronic pancreatitis is supported by identified biomarkers, with improved accuracy in children.
A predictive model for fibrosis severity indicates a promising advancement in patient diagnostics.
Analysis of urine proteomics reveals a panel of proteins specifically associated with the condition.
Improved diagnostic tools could significantly enhance outcomes in pediatric chronic pancreatitis management.

Abstract

We identified a panel of proteins that may diagnose CP in children and developed a model to predict pancreatic fibrosis severity, offering promising tools for improving diagnostics and patient care.

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