Alzheimer's disease as a systems-level timing disorder: Circadian disruption of glial immunometabolism, brain clearance, and therapeutic responsiveness

Key Points

• Therapeutic responsiveness is compromised due to circadian disruption in Alzheimer’s disease.
• Key evidence shows that glial immunometabolism plays a crucial role in this disruption.
• Analysis of circadian rhythms reveals significant impacts on brain clearance mechanisms in Alzheimer’s disease.
• The findings suggest that understanding timing disorders may lead to improved therapies for Alzheimer’s patients.