Inhibition of macrophage pyroptosis by tetrahedral framework nucleic acids delivered celastrol: A novel strategy to attenuate rheumatoid arthritis

Key Points

• Inhibition of macrophage pyroptosis significantly reduces inflammation in rheumatoid arthritis.
• Key evidence shows a 40% decrease in inflammatory markers following treatment with celastrol.
• The study employed tetrahedral framework nucleic acids to deliver celastrol effectively into macrophages.
• This approach may enable better control of rheumatoid arthritis symptoms and improve patient outcomes.