Microglial, astrocytic, oligodendrocyte, B-/T-cell and neutrophil dysregulation in neuroinflammation of Alzheimer's disease and related dementias

Key Points

• Neuroinflammation is associated with the dysregulation of microglia, astrocytes, and oligodendrocytes, impacting disease progression.
• Key findings indicate altered profiles of B-cells and T-cells, as well as an increase in neutrophil activity in affected regions.
• Assessment involved analyzing multiple cell types to understand their contributions to neuroinflammatory processes in dementia.
• This highlights the need for targeted therapies aimed at modulating immune responses in neurodegenerative diseases.