From virtual screening to animal models: chlorhexidine and indinavir as promising anti-Zika drug candidates

Key Points

• Chlorhexidine and indinavir show promise as anti-Zika virus agents, requiring further toxicity assessments.
• Indinavir demonstrated effective antiviral activity, achieving a 90% inhibition of ZIKV replication in cell cultures.
• Integrated computational and experimental methods supported the identification of potential therapeutic molecules.
• Findings underscore the need for further investigation into toxicity before clinical application.